0000011873 00000 n Chemicals in this class of SUHs have been available since the 1960s. List of sulfonylureas Other sulfonylureas Tolazamide Sulfonylurea combinations Duetact (pioglitazone/glimepiride) Glipizide/metformin Glucovance (glyburide/metformin) What are sulfonylureas? Your email address will not be published. In short, once applied to a weed the plant begins to starve and later, as new growth occurs plants die as they cannot make proteins. Occurrence of sulfonylurea, sulfonamide, imidazolinone, and other herbicides in rivers, reservoirs and ground water in the Midwestern United States, 1998. Do not make more than one application in a season except for Bahiagrass. A field agent thought the manager prescribing the low rate was nuts. The herbicides inhibit acetohydroxy acid synthase (AHAS), a key enzyme in the biosynthesis pathway of branched-chain amino acids valine, leucine, and isoleucine in bacteria, fungi, and plants (3, 4, 8, 13).The use of sulfonylurea herbicides has developed . Jerry has written over 100 articles and two books on a wide range of topics such as Turf Pesticides and Nutrition which have been published in Australia and overseas. 0000002086 00000 n tk7T#bJ| }|9$ 5nXOa mMQgSfNvH,TCX5 YZ6 `N0Xavbo3+}FmB*9x[/M9:Zd(\CMy6Qef0>KvrGwcwi$x< Sulfonylurea herbicides used in turfgrassincluding chlorsulfuron, flazasulfuron, foramsulfuron, halosulfuron, metsulfuron, rimsulfuron, sulfometuron, sulfosulfuron, and trifloxysulfuronare all weak acids, with disassociation constants ranging from 3.3 to 5.2. H\@. trailer There is very limited information on the biomonitoring of sulfonylurea herbicides or their metabolites. Sulfonylurea Herbicides causes yellowing or purpling of plants. Available at URL: https://www.epa.gov/fedrgstr/EPA-PEST/2001/December/Day-27/p31800.htmexternal icon. 0000124251 00000 n Sulfonylureas are a unique group of herbicides used for controlling a range of weeds and some grasses in a variety of crops and vegetables. [7] This is further reinforced by a 2020 Cochrane systematic review which did not find enough evidence of reduction of all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke or end-stage renal disease when comparing metformin monotherapy to sulfonylureas. Both herbicide classes act by inhibiting the enzyme acetolactase synthase . b^"YX[06G!5|rg ODB"w_6f"9xbxZ^:*| +3+Jh Afd~V dW\ Ye K P2p R@PxC@%Cw]h2t.6CbPD1*}(.P~\?@Mb& xxQgU~z>XdtG:daf@|J8}yPMhx F Drugs that potentiate or prolong the effects of sulfonylureas and therefore increase the risk of hypoglycemia include acetylsalicylic acid and derivatives, allopurinol, sulfonamides, and fibrates. Some of the herbicides from these classes (eg, chlorsulfuron) are relatively persistent and mobile (Table 1). In the early 1970s, agrichemicals provided DuPont a strong rate of return, but its potential had yet to be fully exploited. /Rotate 0 xref 0000003549 00000 n The side chains R1 and R2 distinguish various sulfonylureas. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. 2023, Gilba Solutions Pty Ltd, All rights reserved. Due to this, . There was not enough data available to determine the risk of mortality or of cardiovascular mortality. Finally, use no more than 200g/Ha per season. Despite this, tracking can occur after morning dew the day after treatment. 0000009543 00000 n Primisulfuron-Methyl. You get the best results when weeds are actively growing. 0000013658 00000 n Overseeding Restriction: Delay oversowing with cool-season turfgrass for 10 days after herbicide application. Sulfonylureas represent a major advance in global crop protection technology and have revolutionized weed control by introducing a unique mode of action. 0000089829 00000 n 7 Sulfonylurea herbicides for turf. 0000050354 00000 n Language links are at the top of the page across from the title. 11 Monument Liquid herbicide (750g/kg Trifloxysulfuron). Use:If the tank water pH is less than 5.5 raise the water pH to 7.0 and do not mix with acidic compounds. DuPont thus built a sustained program of innovation to realize a pioneering inventions scientific and commercial promise. 0000088957 00000 n December 27, 2001. [13] This typically occurs if the dose is too high, and the patient is fasting. Sulfonylurea herbicides work by inhibiting the ALS enzyme which plays an important role in forming necessary proteins for plant growth and development. The SCS/ARS/CES pesticide properties database for environmental decision-making. 0000190627 00000 n In contrast weeds that are under stress will not take up any chemical. Detection of the metabolites may reflect exposure to more than one particular sulfonylurea herbicide or from exposure to environmental degradation products. Biomonitoring data can also help scientists plan and conduct research on exposure and health effects. endstream endstream endobj 605 0 obj<>/Size 554/Type/XRef>>stream That was unheard of. Table showing the weeds controlled by SU herbicides. Sulfonylureas are a group of medicines used in the management of Type 2 diabetes. Sulfonylureas inhibit the plant enzyme, acetolactate synthase, resulting in impaired branch chain amino acid synthesis, and are generally more potent herbicides than the phenylureas. These target temperatures should ideally continue for the week following application. Most SUHs have low volatility, are mobile in soil, and are slightly to moderately soluble in water, so they can leach into runoff and can affect wild aquatic plant growth (Wauchope et al., 1992). The urinary metabolites dimethoxypyrimidine and dimethylpyrimidine can be used as non-specific markers of exposure to the pyrimidinylsulfonylureas, a group that includes bensulfuron-methyl, halosulfuron, primisulfuron-methyl, and sulfosulfon. /Count 3 Sulfonylureas as opposed to metformin, the thiazolidinediones, pramlintide and other newer treatments may induce hypoglycemia as a result of excesses in insulin production and release. 0000104818 00000 n Cosmetics & Personal Care Like insulin, sulfonylureas can induce weight gain, mainly as a result of their effect to increase insulin levels and thus use of glucose and other metabolic fuels. Inhibitorsquizalofop Assure II, Targa Cyclohexanedione clethodim Select, Arrow Amino sethoxydim Poast, Poast Plus Acid2 ALS Inhibitors 38 Sulfonylurea chlorimuron Classic Synthesis(acetolactate synthase) foramsulfuron Option halosulfuron Permit Inhibitorsiodosulfuron Autumn nicosulfuron Accent continued on next page (1 of 3) By Premix These cookies may also be used for advertising purposes by these third parties. << Pharmaceuticals Find us on map After Graduating from Newcastle University with an Hons Degree in Soil Science in 1988, Jerry then worked for the Sports Turf Research Institute (STRI) before emigrating to Australia in 1993. Sulfonylurea herbicides used in turfgrass have variable soil organic matter adsorption, which is soil dependent. The SUHs are often applied for nuisance broadleaf weed and grass control in such noncrop areas as roadsides and drainage ditches, but many also have registered pre- and post-emergence applications for certain crops. endstream endobj 555 0 obj<>/ViewerPreferences<>/Metadata 38 0 R/Pages 37 0 R/StructTreeRoot 40 0 R/Type/Catalog>> endobj 556 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>>/Type/Page>> endobj 557 0 obj<> endobj 558 0 obj<> endobj 559 0 obj<> endobj 560 0 obj<> endobj 561 0 obj<> endobj 562 0 obj<> endobj 563 0 obj<>stream 0000004985 00000 n >> Due to this, herbicide tracking is possible for up to 20 hours after applying; The best result when transitioning ryegrass occurs when the couch is growing aggressively and the ryegrass is killed quickly. 0000124924 00000 n This article can be regarded as a sulfonylurea herbicide list specific to turfgrass. All SUs have the same mode of action and they act by stopping acetolactate synthase (ALS). Dihydromyricetin 0000010373 00000 n Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Industrial & Lab Chemicals, 23661 Birtcher Dr., Lake Forest, CA 92630 Monument Liquid herbicide (750g/kg Trifloxysulfuron). Sulfonylurea herbicides kill weeds by inhibiting the enzyme acetolactate synthase, which is essential to their growth. 2/1/13, U.S. Environmental Protection Agency (U.S. EPA). September 2008. The SUs are classed as Group 2 herbicidesand have become widely used in the turf industry for three main reasons. stream Herbicide performance increases in warm, moist conditions; however, in cold, dry conditions, herbicide activity slows down. << Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. They work on a broad range of grasses and broadleaf weeds, but not on crops they are designed to protect. SU herbicides are useful as weed killers and as spring transition aids to remove cool season grass from couchoversownthe previous autumn. Do not make more than one application in a season except for Bahiagrass. Available at URL: http://ace.ace.orst.edu/info/extoxnet/pips/primisul.htmexternal icon. 2(R_&yN$S`o0-^&7`70SaI~0B6=[3wk3iTFU kiV6r("xFZ%e(ohx5*J~y3Oy1&CG(Le[MetOKLR=\W/5lDvBG D.z_Q3C/@[t5K)f9&LNKRdYu1'"J?}k(L3x! A highly active herbicide (a combination of three sulfonylurea herbicides) with foliar and some root activity against black-grass, wild oats, rye-grasses, bromes, meadow-grass, cleavers, common chickweed, mayweeds, charlock and volunteer oilseed rape in winter wheat. Field experiments were carried out during 1997 and 1998 in northern Greece to investigate the effects of tank mixing rimsulfuron and primisulfuron with atrazine or dicamba against johnsongrass in corn. General: In short Negate contains two sulfonylurea herbicides and you use it to control winter grass, ryegrass, onion grass, and certain broadleaf weeds. 5 70 Battaglin WA, Furlong ET, Burkhardt MR, Peter CJ. (949) 468 0555 Chondroitin Sulfate 0000013399 00000 n endobj This Federal Register Notice also announces the availability of draft registration review human health and ecological risk assessments for an additional 13 pesticide chemicals that are not sulfonylureas. May 12, 1999a. However,they can be lethal to cool-season grassessuch as ryegrass, bentgrass, Poa annua,tall fescue, and Poa trivialis. To reduce the potential for any issues, water the morning afterwards and try and leave a 3 metre buffer around areas of creeping bentgrass. -EqbL8-dM=I lgoi[Gh{&7M'd}slmnf4w{9Mz`fo4^%vpWf8~QdvMV?5ssTm7.&U_F_:=M 5"=+[=ge4t]lr/iI|K;8%y 9 \,`O`:::*U0@V&t+&}>BG#}>BG#5A #93#3#37-ucLc2O>hS^- 'u 0000105256 00000 n For example, you can safely use Prosedge for sedge control in both cool- and warm-season turfgrass. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Getting the Best results from the SU herbicides. Class of organic compounds used in medicine and agriculture, . << He followed this by gaining a Grad Dip in Business Managment from UTS and has worked in a number of managment roles for companies as diverse as Samsung Australia, Arthur Yates and Paton Fertilizers. Always apply with a non-ionic surfactant, for example BS1000 or Hasten at the label rate. [21], There is some evidence that sulfonylureas also sensitize -cells to glucose, that they limit glucose production in the liver, that they decrease lipolysis (breakdown and release of fatty acids by adipose tissue) and decrease clearance of insulin by the liver. Tolerant Turfgrass: Use Negate on common and hybrid ouch, zoysia, and also Qld Blue Couch. 0000096304 00000 n ;pn#~=8**`)AS`PxHj /w|INB,F3S}%r|R+B$n[XFyGv3eIN-ix/7C6[. Sulfonylureas lower blood glucose levels by stimulating insulin release from the Beta cells of the pancreas. [15] An earlier review by the same group found a statistically significant increase in the risk of cardiovascular death for first generation sulfonylureas relative to placebo (RR 2.6) but there was not enough data to determine the relative risk of first generation sulfonylureas relative to insulin (RR 1.4). HWr64$Oi)Jb#*Mu E#J^9`f(2 The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. /Type /Page Revised June, 1996. To get the best results you need to use with a non-ionic surfactant such as BS1000. AllowTributeto dry before traffic, as this avoids damage to cool-season turfgrass due to tracking. Many newer SUHs are nontoxic to slightly toxic to birds and aquatic insects and vertebrates, although with massive accidental spills into rivers, fish kills have been reported. 0000141194 00000 n 0000005625 00000 n 8 0 obj Estimated human intakes associated with registered uses have been below recommended limits (U.S. EPA, 2002, 2004a, 2004b, and 2008). xbbg`b``3 1^` x 8 Sulfosulfuron; pesticide tolerance. Specifically, these compounds interfere with a key enzyme required for weed cell growth acetolactate synthase. They include glimepiride, although it is sometimes considered a second-generation drug. 2023 CRO & CRAO Digital Map invite your participating, Laborotory | Field | Regulatory | Registration | Seeds. And the herbicides are safe for humans and animals because they do not have the enzyme sulfonylurea molecules target. The information is provided by Gilba Solutions and while we try to keep it up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, or suitability with respect to the website or the information, products, or services, on the website for any purpose. use these when the average air temperatures are 18C or higher, and/or when average soil temperatures at a depth of 150mm are 21C or higher. <<23A709F3BDED8C44A2218EB2BC5A8240>]>> 0000002554 00000 n Accent nicosulfuron Sulfonylurea 2 Acclaim Extra fenoxaprop Aryloxyphenoxy-propionate 1 Acumen pendimethalin Dinitroaniline 3 Aim carfentrazone Triazolinone 14 Alachlor alachlor Chloroacetamide 15 . 377-409. HWmO9Ji*J&S^Mx 5S3k{y;21yYq&!FqfQa\1}WGgwV4w1tL's4$s9JnI&![53]wk`HrgS$1Ik)n5fVoH All rights reserved. xref Since all have the same mode of action, you should rotate with other herbicides from other groups; Avoid spray drift due to the chance of non target damage; Some SUs need watering in whilst others recommend the use of spray surfactants. [14], A 2020 Cochrane systematic review comparing metformin monotherapy to sulfonylureas did not find enough evidence of reduction of all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke or end-stage renal disease.[8]. %PDF-1.3 Combined with the low application rates, selectivity for a variety of crops, and short half-life, sulfonylurea herbicides were a revolutionary advance in agrichemicals and an important cornerstone of DuPonts change in corporate strategy in the 1980s. Available at URL: https://www.epa.gov/pesticides/external iconreregistration/REDs/chlorimuronethyl_tred.pdf.2/1/13, U.S. Environmental Protection Agency (U.S. EPA). We comply with the HONcode standard for trustworthy health information. Corn grain yield was less when sulfonylurea herbicides were applied alone compared to when they were applied with 2,4-D + MCPA. Halosulfuron-methyl; pesticide tolerances for emergency exemptions. Their high specificity means that turfgrass tolerance varies. Herbicide families that have persistent members include triazines, uracils, phenylureas, sulfonylureas, dinitroanilines, isoxazolidiones, imidazolinones, and certain plant growth regulators belonging to the pyridine family. /Parent 1 0 R Usually, after 7 10 days you can see the first signs of damage and the full effects are seen after 4-6 weeks. /Length 1438 0000005736 00000 n 0000122469 00000 n /MediaBox [ 0 0 608 785 ] 0000092176 00000 n The urinary metabolite methoxymethyl triazine can be used as a non-specific marker of exposure to the triazinylsulfonylureas, a group that includes chlorosulfuron, prosulfuron, and triasulfuron. << 2006-2023 Chongqing Stanley Info-tech Co.,Ltd. McCullough and Hart (2010) found the most successful rate for. Sci Total Environ 2000;248(2-3):123-33. So aim to use these when the average air temperatures are 18C or higher, and/or when average soil temperatures at a depth of 150mm are 21C or higher. >> uBnZ"3\Cyu@b7T. Continuing to use this chemical group and not rotating to other groups means that at some stage sulfonylurea-resistant weeds are likely to develop. 0000007487 00000 n 0000004134 00000 n H\j0E Do you use Twitter? Sulfonylureas were discovered, in 1942, by the chemist Marcel Janbon and co-workers,[24] who were studying sulfonamide antibiotics and discovered that the compound sulfonylurea induced hypoglycemia in animals.[25]. endobj As a result, it is recommended to use a water rate of 200-500 L/ha. The product's label states that is kills sedge and kyllinga fast. Report of the Food Quality Protection Act (FQPA) Tolerance Reassessment Progress and Risk Management Decision (TRED) for Chlorimuron Ethyl. endstream endobj 564 0 obj<> endobj 565 0 obj<> endobj 566 0 obj<> endobj 567 0 obj<>stream Sodium Hyaluronate Used in Anterior Segment Eye Surgery, High VS. Low Molecular Weight Hyaluronic Acid, Medical-grade Sodium Hyaluronate Guide 2023: Functions & Applications. In this situation, the couch rapidly fills in the dead areas and there is minimal disruption. We take your privacy seriously. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. endstream endobj 568 0 obj<>stream /Type /Catalog 0000124516 00000 n Application no later than the fully tillered stage is recommended for better spray coverage on weeds. 0000014937 00000 n You will be subject to the destination website's privacy policy when you follow the link. 2/1/13. Many sulfonylurea herbicides are verysafe on warm-season grasses. These all have the same mode of action and so the issue of herbicide resistance is a problem. /Thumb 25 0 R These include bindii, caustic weed, white clover, Cobblers Peg, Creeping Indigo, Creeping Oxalis, Plantain, and Daisy. These herbicides are taken up by the roots and foliage and act by disrupting protein synthesis. ' }K2F$0$h32@H5\THi^E` grfX%xAdO>eA4z61r';p]Hw7%TUw{ d&5$e,xL{6o(!\'?I'\1. Second, due to their low level of mammalian toxicity and finally, because they have a very low impact on the environment. . Cookies used to make website functionality more relevant to you. They can be divided into the pyrimidinylsulfonylureas and the triazinylsulfonylureas. 0000019178 00000 n Harmony Extra can be applied in wheat after the two-leaf stage but before the flag leaf is visible. startxref Reviewer 1 Report Dear authors, After carrying out the review of the article entitled "Risk assessment of sulphonylurea herbicides based on a complex bioindicator", proposed for possible publication in Agriculture Journal would like to express that from my perspective the work is interesting, and the topic is relevant from the environmental point of view. << 0000011899 00000 n Some SUs need watering in whilst others recommend the use of. This class of herbicide works well in soil of low pH, it absorbs easier and is more persistent. But DuPont would have profited only modestly from sulfonylurea herbicides were it not for a new research manager willing to take a risk and ramp up an innovation program that was being curtailed. Urinary levels of the sulfonylurea herbicides reflect recent exposure. Report of the Food Quality Protection Act (FQPA) Tolerance Reassessment Progress and Risk Management Decision (TRED) for Nicosulfuron. Most SUHs are resistant to hydrolysis and oxidation under environmental conditions but are only moderately persistent because they are degraded by soil microorganisms. After applying, growth slows within the first few days and chlorotic patches start to appear. Bo>.>dj@~*"o,$p'q^l;[cIBL{f;20xd' Bx As a result, take great care when applying Coliseum near, or on slopes that drain onto, cool-season grasses. 0000064141 00000 n 0000005100 00000 n 0000018164 00000 n Other points of note: Dont mix with a surfactant or crop oil as it causes yellowing in tolerant turf; Nominee claims to be slow acting. /Resources 30 0 R LLP}~t-&iGf&vE_*Zi4>hBg!&gc!/h!">i\/%G%Rjt+|l'H?VrpaGo:Q5NR]LQrBJE Ss*^V^i68d^89aSNYab`Fl9*_5VGCee#Y H\n@ELPU,983 x(# A_*z qla~b~pw};-\]p U~g9e?bb?zu>9zptY7eK{m 0000088293 00000 n In a 1998 survey, nicosulfuron was detected in 67% of 130 Midwestern streams and rivers (Battaglin et al., 2000). 0000006766 00000 n 0000175586 00000 n This article is a free guide to all the turf registered sulfonylurea (SU) herbicides in Australia. Tolerant Turfgrass: Use on Kikuyu, buffalograss, or couch (common and hybrid couch) but NOT on Queensland Blue Couch. Most SUHs bind to soils and are taken up by plant roots. >> [online] December 2004b. 0000025743 00000 n 0000125767 00000 n [6], While prior sulfonylureas were associated with worse outcomes, newer agents do not appear to increase the risk of death, heart attacks, or strokes. In addition, Harmony Extra is a prepackaged mixture of the sulfonylurea herbicides thifensulfuron-methyl and tribenuron-methyl. Negate (167 g/kg Rimsulfuron and200 g/kg Metsulfuron-methyl), SU herbicides are useful as weed killers and as, These all have the same mode of action and so the issue of herbicide resistance is a problem. @5?vGDA=GZ9 +a!! 0000015781 00000 n These herbicides are generally only slightly toxic to freshwater fish and invertebrates, and practically nontoxic to wildfowl and other mammals. 0000123472 00000 n Rev Environ Contam Toxicol 1992;123:1-155. 0000161846 00000 n An attractive feature of sulfonylureas is that they can be applied at relatively low application rates. Their action is dependent upon the presence of functioning Beta cells, therefore, sulfonylureas do not work in people with type 1 diabetes. Use Pattern: Use Monument on golf courses, sod farms, and other non-residential sites. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. General: Use to control winter grass and also as a spring transition aid in overseeded couch. These herbicides can either be pre-emergent or post-emergent herbicides and are systemic or work on the leaf surface. Monument is rainfast within 3 hours of application. [26], A large number of sulfonylureas are used as herbicides. 0000124991 00000 n (949) 812 6690 The safety of sulfonylurea therapy in pregnancy is unestablished. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. /Contents 24 0 R 0000147373 00000 n al. [6] Still, it is important to highlight that the studies available to be included in this review presented considerable flaws in quality and design. HERBICIDE BRAND NAMES, ACTIVE INGREDIENTS, CHEMICAL FAMILIES, AND MODES OF ACTION (continued) Category; Iofensulfuron: 1144097-22-2: Herbicides > Sulfonylurea Herbicides: Trifloxysulfuron : 145099-21-4,199119-58-9: Herbicides > Sulfonylurea Herbicides . 0000105614 00000 n Halosulfuron; pesticide tolerance. They have been extremely popular worldwide because of their low mammalian toxicity, low use rate, and unprecedented herbicidal activity. 5 0 obj <> endobj 0000101024 00000 n Copyright 2010-2023 Stanford Chemicals owned by Oceania International LLC, All Rights Reserved. Finding a measurable amount of a sulfonylurea herbicide or metabolites in the urine does not imply that the levels of sulfonylurea herbicide or metabolites cause an adverse health effect. Sequential applications, where the johnsongrass herbicides were applied 5 d after the broadleaf herbicides, were also evaluated. The store will not work correctly in the case when cookies are disabled. Application Date: 01/02/2018 . Whats more, on juvenile turfg delay applying until there is 100% ground cover, and there is a 50mm root depth. 0000126372 00000 n Weeds have naturally-occurring biotypes that are resistant to these herbicides. 0000016578 00000 n "Comparative in vitro equivalence evaluation of some local Gliclazide brands of Bangladesh", "Neonatal diabetes mellitus: a model for personalized medicine", "Interventions for latent autoimmune diabetes (LADA) in adults", "Correction: The Association between Sulfonylurea Use and All-Cause and Cardiovascular Mortality: A Meta-Analysis with Trial Sequential Analysis of Randomized Clinical Trials", "Metformin monotherapy for adults with type 2 diabetes mellitus", "Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus", "Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus", "A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases", "Glucagon-like peptide analogues for type 2 diabetes mellitus", "Sulfonylurea versus metformin monotherapy in patients with type 2 diabetes: a Cochrane systematic review and meta-analysis of randomized clinical trials and trial sequential analysis", "Effects of intensive glucose lowering in type 2 diabetes", "Glucose control and vascular complications in veterans with type 2 diabetes", "Sulfonylurea stimulation of insulin secretion", "New weapons to combat an ancient disease: treating diabetes", https://en.wikipedia.org/w/index.php?title=Sulfonylurea&oldid=1147296929, Articles unintentionally citing retracted publications, Short description is different from Wikidata, Articles with unsourced statements from February 2023, Articles with unsourced statements from June 2016, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 30 March 2023, at 01:02.